A Closer Look at Lewy Bodies
Since the early 1900s, Lewy bodies have been a primary distinguishing feature of Parkinson’s disease pathology. First described by Dr. Friederich Lewy in 1912, Lewy bodies appear under light microscopes as large sphere-shaped masses in neuronal cell bodies and are accompanied by spindle-like inclusions in neuronal process referred to as Lewy neurites.1 In addition to aggregated alpha synuclein and ubiquitin, Lewy bodies contain at least 90 other molecules.2 Lewy Bodies and Neurites Lewy bodies (round brown/black structures) and Lewy neurites…