Transplanted Cells in Parkinson’s Disease Continue to Inform
It’s been nearly a decade since groups in the United States1 and Sweden2 reported alpha synuclein pathology in transplanted cells grafted into the brains of people with Parkinson’s disease. The Lewy body-like inclusions were accompanied by other markers of neuronal dysfunction that apparently developed over 10+ years. The pathology is remarkable because the transplanted cells were young and genetically unrelated to the individuals with Parkinson’s disease, suggesting an ongoing degenerative process in the parkinsonian brain and the presence of a pathological…